Bacterial infections may elevate the risk of coronary heart disease in individuals with type 1 diabetes, according to results from a study published in the Journal of Internal Medicine.
Antibiotic purchases reflecting bacterial infections in outpatient care were significant risk factors for coronary heart disease, with a 21% increased risk for each annual antibiotic purchase.
Further, a high blood level of bacterial lipopolysaccharides, or large molecules derived from the outer layer of gram-negative bacteria, was also a risk factor for coronary heart disease, according to the study.
"In broader terms, the present study demonstrates how infections associate with the development of late diabetic complications and perhaps even more importantly, how infections associate with the development of coronary heart disease, as the latter relationship has been disputed during recent years," said study author Johan Rasmus Simonsen, MD, of the Folkhälsan Research Center, in Finland, in a press release. "Interestingly, in our study this association to incident coronary heart disease was seen specifically with antibiotic purchases, making the potential pathophysiologic mechanisms behind this finding intriguing and warranting further studies."