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Applying Guidelines in Practice: Noninvasive Prenatal Testing

Applying Guidelines in Practice: Non-Invasive Prenatal Testing
This supplement is designed to provide ObGyn clinicians with current information on the cell-free DNA screening test options available for fetal ch...

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  • Overview

    This supplement is designed to provide ObGyn clinicians with current information on the cell-free DNA screening test options available for fetal chromosomal abnormalities. These screening tests are commonly referred to as Noninvasive Prenatal Testing (NIPT). In August 2020, the American College of Obstetricians and Gynecologists issued a Practice Bulletin entitled “Screening for Fetal Chromosomal Abnormalities (PB #226). This Practice Bulletin included expanded information regarding the use of NIPT in all patients regardless of maternal age or baseline risk. It also identified NIPT as the most sensitive and specific test for screening for the most common aneuploidies. The authors of this supplement provide additional information on the technology, performance, and clinical utilization of Noninvasive Prenatal Testing .

  • Disclosure of Conflicts of Interest

    In accordance with the ACCME Standards for Commercial Support, Global Learning Collaborative (GLC) requires that individuals in a position to control the content of an educational activity disclose all relevant financial relationships with any commercial interest. GLC resolves all conflicts of interest to ensure independence, objectivity, balance, and scientific rigor in all its educational programs.


    Genevieve Fairbrother, MD, MPH, FACOG      
    Chief Medical Officer
    Atlanta Women’s Health Group
    Northside Hospital System
    Atlanta, GA
    Dr. Fairbrother has nothing to disclose.

    Morry Fiddler, PhD                                      
    Insight Medical Genetics
    Professor Emeritus, DePaul University
    Chicago, IL
    Salary: Insight Medical Genetics.

    Lee Philip Shulman, MD, FACOG, FACMG
    The Anna Ross Lapham Professor and Chief
    Division of Clinical Genetics
    Feinberg School of Medicine of Northwestern University
    Chicago, IL
    Consulting Fees: Biogix, Celula, Cooper Surgical, Natera, Vermillion/Aspira
    Commercial Interest Speakers Bureau: Bayer, Lupin Pharmaceuticals, Inc., Myriad

    Andrew F. Wagner, MD, FACMG, FACOG              
    Associate Professor
    Feinberg School of Medicine
    Northwestern University
    Chicago, IL
    Dr. Wagner has nothing to disclose.

    Haichuan Zhang, PhD
    Celula Medical Technology Co.
    Chengdu, China
    Ownership interest: Celula China Medical Technology Co.

    Reviewers/Content Planners/Authors:

    • Ann Early has nothing to disclose.
    • Barry A. Fiedel, PhD has nothing to disclose.
    • Amanda Hilferty has nothing to disclose.
    • Robert Schneider, MSW has nothing to disclose.
  • Learning Objectives

    After participating in this educational activity, participants should be better able to:

    • Overcome barriers and demonstrate competency in integrating ACOG/SMFM Non-Invasive Prenatal Testing Committee Opinions/Practice Bulletins recommendations into clinical decision-making surrounding prenatal visits for all pregnant patients.
    • Explain the benefits and disadvantages of traditional fetal chromosomal aneuploidy screening tests compared with non-invasive screening tests.
    • Define the technology that is the basis of the various non-invasive screening tests, including the role that fetal fraction plays in influencing results.
    • Explain the expanding role of non-invasive prenatal testing in the general obstetrical population.

  • Accreditation and Credit Designation Statements

    Global Learning Collaborative is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

    Global Learning Collaborative designates this enduring material for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

  • Target Audience

    This activity is designed to meet the educational needs of the obstetrician and gynecologist, family physician, internal medicine physician, physician assistant, nurse practitioner, and certified nurse midwife.

  • Provider(s)/Educational Partner(s)

    ReachMD Healthcare Image

    Omnia Education is the leading provider of education for women’s health professionals. Our activities are recognized nationwide for providing credible, relevant, and practical information on issues impacting the female patient. Additionally, our unique focus has transformed the CME learning environment, and our ability to help learners recognize and overcome barriers to optimal performance and optimal patient outcomes has positioned us as a leader in women’s health education.

  • Commercial Support

    This activity is supported by an independent educational grant from Roche Diagnostics.

  • System Requirements

    Our site requires a computer, tablet, or mobile device and a connection to the Internet. For best results, a high-speed Internet connection is recommended (DSL/Cable/Fibre). We also recommend using the latest version of your favorite browser to ensure compliance with W3C standards, such as Chrome, Safari, Firefox, or Microsoft Edge.

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