Hemolytic Disease of the Fetus and Newborn: Cutting Edge Strategies for Diagnosis and Management

Hemolytic Disease of the Fetus and Newborn: Cutting Edge Strategies for Diagnosis and Management

Hemolytic Disease of the Fetus and Newborn: Cutting Edge Strategies for Diagnosis and Management

HDFN is a rare condition affecting a small population of pregnancies. Here, we discuss strategies for its diagnosis and management.

Available credits: 0.25

Time to complete: 15 minutes


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  • Overview

    Hemolytic disease of the fetus and newborn (HDFN) is a rare condition with an estimated 3-80 cases per 100,000 pregnancies in the US every year. HDFN occurs when maternal red blood cells or blood group antibodies cross the placenta during pregnancy and cause fetal red cell destruction. The physiologic consequences of severe anemia in the fetus can lead to edema, ascites, hydrops, heart failure, and even death.

    This activity provides strategies for the diagnosis and management of HDFN, including available algorithms for diagnosis and follow-up therapy.

  • Disclosure of Conflicts of Interest

    In accordance with the ACCME Standards for Commercial Support, Global Learning Collaborative (GLC) requires that individuals in a position to control the content of an educational activity disclose all relevant financial relationships with any commercial interest. GLC resolves all conflicts of interest to ensure independence, objectivity, balance, and scientific rigor in all its educational programs.

    Lee P. Shulman, MD, FACMG, FACOG
    The Anna Ross Lapham Professor in Obstetrics and Gynecology
    Feinberg School of Medicine
    Northwestern University
    Chicago, IL 

    Consulting Fees: Biogix, Celula, CooperSurgical, Natera, Vermillion/Aspira
    Commercial Interest Speakers Bureau: Bayer, Lupin Pharmaceuticals, Inc., Myriad 

    Kenneth J. Moise Jr., MD
    Professor of Obstetrics and Gynecology, Dell Medical School
    Director, Comprehensive Fetal Care Center
    Dell Children's Medical Center
    Austin, TX 

    Royalties: UpToDate, Inc.
    Contracted Research: Momenta Pharmaceuticals Inc. 

    Reviewers/Content Planners/Authors:

    • Sean T. Barrett has nothing to disclose.
    • Barry A. Fiedel, PhD, has nothing to disclose.
    • Amanda Hilferty has nothing to disclose.
    • Brian P. McDonough, MD, FAAFP, has nothing to disclose.
    • Robert S. Schneider, MSW, has nothing to disclose. 
  • Learning Objectives

    After participating in this educational activity, participants should be better able to:

    • Explain the pathophysiology underlying fetal/newborn alloimmune diseases, with a focus on HDFN.
    • Identify current diagnostic and treatment regimens for HDFN.
    • Explain the role of the neonatal Fc receptor pathway as a therapeutic means to address HDFN.
  • Target Audience

    This activity is designed to meet the educational needs of maternal-fetal medicine specialists, obstetricians/gynecologists, nurse practitioners, nurses, and physician assistants.

  • Accreditation and Credit Designation Statements

    Global Learning Collaborative is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

    Global Learning Collaborative designates this enduring material for a maximum of .25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

  • Provider

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    Omnia Education is the leading provider of education for women’s health professionals. Our activities are recognized nationwide for providing credible, relevant, and practical information on issues impacting the female patient. Additionally, our unique focus has transformed the CME learning environment, and our ability to help learners recognize and overcome barriers to optimal performance and optimal patient outcomes has positioned us as a leader in women’s health education.

  • Commercial Support

    This activity is supported by an independent educational grant from Momenta Pharmaceuticals.

  • Disclaimer

    The views and opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of GLC and Omnia Education. This presentation is not intended to define an exclusive course of patient management; the participant should use his/her clinical judgment, knowledge, experience, and diagnostic skills in applying or adopting for professional use any of the information provided herein. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patients’ conditions and possible contraindications or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities. Links to other sites may be provided as additional sources of information. Once you elect to link to a site outside of Omnia Education you are subject to the terms and conditions of use, including copyright and licensing restriction, of that site.

    Reproduction Prohibited

    Reproduction of this material is not permitted without written permission from the copyright owner.

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