Got Prunes? Prunes May Preserve Bone Density and Strength in Older Women

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06/26/2024

It’s of particular concern among postmenopausal women, the researchers said. Estrogen, a hormone critical for bone health, declines during this life phase and lower levels of estrogen hastens the loss of bone density. While there is medication available to treat osteoporosis, the researchers said that many women who should be taking it aren’t.

Prunes offer a promising alternative, according to De Souza. They contain bioactive compounds like polyphenols that may blunt the inflammatory pathways that lead to bone loss.

Prior studies primarily used dual energy X-ray absorptiometry (DXA) to evaluate 2D bone mass density and to diagnose osteoporosis. But DXA scans can’t distinguish between different types of bone tissue or measure the structural properties of bone, which can serve as a proxy for bone strength and quality, the researchers explained.

“When we look at bone mineral density, we’re looking at how much bone there is, but we also want to know about the quality of the bone. When we look at a three-dimensional picture, we can look at bone structure, geometry and micro-architecture. In other words, it tells us how good the bone is,” De Souza said.

To see whether daily prune consumption influenced bone quality, the research team conducted a 12-month randomized controlled trial with 235 postmenopausal women. Participants were assigned to one of three groups: no prunes; 50 grams, or four to six, prunes daily; or 100 grams, or 10 to 12, prunes daily. Every six months, they were assessed using a peripheral quantitative computed tomography, or pQCT, scan, which allows for cross-sectional imaging to measure 3D bone mass density, bone geometry and bone strength.

Over the course of one year, the researchers found that measures of bone mass density and bone strength at the tibia, or shin bone, all decreased in women in the control group. In contrast, those who ate at least four to six prunes every day maintained bone density and bone strength and preserved bone structure, particularly in cortical bone. While women in both prune groups saw benefit, four to six prunes a day may be the more feasible dose. Women in the 100-gram group dropped out of the study at a higher rate because they got bored of incorporating so many prunes into their daily diet.

“It’s pretty exciting data for a 12-month study,” De Souza said. “We were able to maintain and preserve bone at the weight-bearing, cortical bone of the tibia and the maintenance of cortical bone and bone strength is key to avoiding fracture.”

Prune consumption could also potentially reduce the risk of osteoporosis, De Souza explained, but more research is needed.

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